Research – Gonzalo Lab
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization | PNAS
Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase | Aging
Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria - ScienceDirect
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization | PNAS
About Progeria
Mechanics in human fibroblasts and progeria: Lamin A mutation E145K results in stiffening of nuclei - Apte - 2017 - Journal of Molecular Recognition - Wiley Online Library
Francis Villatoro on X: "#Nature In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice (by David R. Liu et al.) https://t.co/YvqGq0aSGg Progeria is typically caused by a dominant-negative C•G-to-T•A mutation (c.1824
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization | PNAS
Progeria: What Is It, Causes, Clinical Presentation, and More | Osmosis
Progeria: A Paradigm for Translational Medicine: Cell
Progerin - Wikipedia
Progeria Gene Implicated in Normal Aging | National Institutes of Health (NIH)
Aging: Progeria and the Lamin Connection - ScienceDirect
Increased expression of the Hutchinson–Gilford progeria syndrome truncated lamin A transcript during cell aging | European Journal of Human Genetics
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization | PNAS
Genes | Free Full-Text | Splicing Variants, Protein-Protein Interactions, and Drug Targeting in Hutchinson-Gilford Progeria Syndrome and Small Cell Lung Cancer
Normal and Hutchinson-Gilford progeria syndrome nuclei differ in... | Download Scientific Diagram
JCI Insight - Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome
Lamin A Truncation in Hutchinson-Gilford Progeria | Science
Molecular mechanisms underlying immature lamin A-induced progeria.... | Download Scientific Diagram
Invecchiamento precoce da progeria | ACSA
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome | PNAS
JCI - Interruption of progerin–lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype
CRISPR base editor treats premature-aging syndrome | Signal Transduction and Targeted Therapy
